Pain Evaluated as Pyoderma Gangrenosum Outcome Measure

TOPLINE:

A 2-point improvement in pain based on a numeric rating scale may indicate that patients are responding to treatment for pyoderma gangrenosum.

METHODOLOGY:

• To help determine whether a patient with pyoderma gangrenosum is responding to treatment, researchers used a patient global assessment (PGA) score to establish a minimal important difference (MID) in the measure of pain.

• The MID was analyzed as median change in pain associated with each magnitude of absolute change in PGA score in 43 patients from a pyoderma gangrenosum registry at Oregon Health & Science University from June 2021 to June 2022.

• PGA was the anchor measure, a 5-point scale in which patients described their skin condition as clear, almost clear, mild, moderate, or severe. Other data obtained from the registry included ulcer…