The winless Los Angeles Lakers fell to 0-5 to start the season with a 111-102 loss at Minnesota.
The Timberwolves were led by a game-high 29 points from Anthony Edwards plus 22 points and 21 rebounds by Rudy Gobert.
James had 28 points, seven rebounds, five assists and four steals in a losing cause.
Lakers coach Darvin Ham said his team’s 22 turnovers, leading to 25 Minnesota points, were too much to overcome.
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“For me, the most glaring stat is the turnovers,” he said. “When you give them 22 turnovers, 25 points, it’s very hard to win in this league. We have to do a better job of valuing possessions.”